Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC

In the last decade, there were 10 million new tuberculosis cases per year globally. Around 9.5% of these cases were caused by isoniazid resistant (INHr) Mycobacterium tuberculosis (Mtb) strains. Although isoniazid resistance in Mtb is multigenic, mutations in the catalase-peroxidase (katG) gene pred...

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Publicado en:PLoS One
Autores principales: Nieto R, Luisa Maria, Mehaffy, Carolina, Creissen, Elizabeth, Troudt, JoLynn, Troy, Amber, Bielefeldt-Ohmann, Helle, Burgos, Marcos, Izzo, Angelo, Dobos, Karen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125630/
https://ncbi.nlm.nih.gov/pubmed/27893795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166807
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