Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration

Complement dysregulation plays a key role in the pathogenesis of age-related macular degeneration (AMD), but the specific mechanisms are incompletely understood. Complement also potentiates retinal degeneration in the murine light damage model. To test the retinal function of CD59a, a complement inh...

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Veröffentlicht in:PLoS One
Hauptverfasser: Song, Delu, Wilson, Brooks, Zhao, Liangliang, Bhuyan, Rupak, Bandyopadhyay, Mausumi, Lyubarsky, Arkady, Yu, Chen, Li, Yafeng, Kanu, Levi, Miwa, Takashi, Song, Wen-Chao, Finnemann, Silvia C., Rohrer, Bärbel, Dunaief, Joshua L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125596/
https://ncbi.nlm.nih.gov/pubmed/27893831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166348
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