Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis

Beta amyloid (Aβ) triggers the elimination of excitatory synaptic connections in the CNS, an early manifestation of Alzheimer's disease. Oligomeric assemblies of Aβ peptide associate with excitatory synapses resulting in synapse elimination through a process that requires NMDA-type glutamate re...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Sinnen, Brooke L., Bowen, Aaron B., Gibson, Emily S., Kennedy, Matthew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2016
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125218/
https://ncbi.nlm.nih.gov/pubmed/27911757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1603-16.2016
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