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Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines

Gene silencing by small interfering RNA (siRNA) is useful for analyzing the functions of human immune cells. However, the transfection of siRNA to human immune cells is difficult. Here, we used a multifunctional envelope-type nanodevice (MEND) containing YSK12-C4 (YSK12-MEND) to efficiently introduc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nakamura, Takashi, Kuroi, Moeka, Fujiwara, Yuki, Warashina, Shota, Sato, Yusuke, Harashima, Hideyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124971/
https://ncbi.nlm.nih.gov/pubmed/27892533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37849
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