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Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines

Gene silencing by small interfering RNA (siRNA) is useful for analyzing the functions of human immune cells. However, the transfection of siRNA to human immune cells is difficult. Here, we used a multifunctional envelope-type nanodevice (MEND) containing YSK12-C4 (YSK12-MEND) to efficiently introduc...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Nakamura, Takashi, Kuroi, Moeka, Fujiwara, Yuki, Warashina, Shota, Sato, Yusuke, Harashima, Hideyoshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124971/
https://ncbi.nlm.nih.gov/pubmed/27892533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37849
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