Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning.
Combinatorial libraries of antibody heavy and light chains derived from the peripheral blood lymphocytes of an individual immunized with tetanus toxoid have been expressed in Escherichia coli by using phage lambda vectors. Screening of the libraries allowed identification of a large number of human...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1991
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1826052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2432 |
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