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Interleukin 1 Beta Mediates Intestinal Inflammation in Mice and Patients with IL10 Receptor Deficiency

IL10 receptor (IL10R)-deficient mice develop spontaneous colitis and similarly, patients with loss-of-function mutations in IL10R develop severe infant-onset inflammatory bowel disease (IBD). Loss of IL10R signaling in mouse and human macrophages is associated with increased production of interleuki...

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Pubblicato in:Gastroenterology
Autori principali: Shouval, Dror S., Biswas, Amlan, Kang, Yu Hui, Griffith, Alexandra E., Konnikova, Liza, Mascanfroni, Ivan D., Redhu, Naresh S., Frei, Sandra M., Field, Michael, Doty, Andria L., Goldsmith, Jeffrey D., Bhan, Atul K., Loizides, Anthony, Weiss, Batia, Yerushalmi, Baruch, Yanagi, Tadahiro, Lui, Xiuli, Quintana, Francisco J., Muise, Aleixo M., Klein, Christoph, Horwitz, Bruce H., Glover, Sarah C., Bousvaros, Athos, Snapper, Scott B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124405/
https://ncbi.nlm.nih.gov/pubmed/27693323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2016.08.055
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