Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD

Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported significant alterations in innate and adaptive immune responses in these patients. Next generation sequenc...

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Vydáno v:Front Immunol
Hlavní autoři: Werner, Lael, Lee, Yu Nee, Rechavi, Erez, Lev, Atar, Yerushalmi, Baruch, Ling, Galina, Shah, Neil, Uhlig, Holm H., Weiss, Batia, Somech, Raz, Snapper, Scott B., Shouval, Dror S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017840/
https://ncbi.nlm.nih.gov/pubmed/32117262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00109
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