CRY2 and FBXL3 cooperatively degrade c-MYC

For many years, a connection between circadian clocks and cancer has been postulated. Here, we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation. c-MYC is a critical regulator of...

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Udgivet i:Mol Cell
Main Authors: Huber, Anne-Laure, Papp, Stephanie J., Chan, Alanna B., Henriksson, Emma, Jordan, Sabine D., Kriebs, Anna, Nguyen, Madelena, Wallace, Martina, Li, Zhizhong, Metallo, Christian M., Lamia, Katja A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123859/
https://ncbi.nlm.nih.gov/pubmed/27840026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.10.012
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