Cohesin removal along the chromosome arms during the first meiotic division depends on a NEK1-PP1γ-WAPL axis in the mouse

Mammalian NIMA-like kinase-1 (NEK1) is a dual-specificity kinase highly expressed in mouse germ cells during prophase I of meiosis. Loss of NEK1 induces retention of cohesin on chromosomes at meiotic prophase I. Timely deposition and removal of cohesin is essential for accurate chromosome segregatio...

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Publicat a:Cell Rep
Autors principals: Brieño-Enríquez, Miguel A., Moak, Stefannie L., Toledo, Melissa, Filter, Joshua J., Gray, Stephen, Barbero, José L., Cohen, Paula E., Holloway, J. Kim
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123770/
https://ncbi.nlm.nih.gov/pubmed/27760328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.059
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