Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

BACKGROUND: Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimer’s disease (AD). Increasing evidence suggests that insulin resistance plays an important role in AD pathogenesis, possibly due to abnormal GSK3β activa...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Ng, Roy Chun-Laam, Cheng, On-Yin, Jian, Min, Kwan, Jason Shing-Cheong, Ho, Philip Wing-Lok, Cheng, Kenneth King-Yip, Yeung, Patrick Ka Kit, Zhou, Lena Lei, Hoo, Ruby Lai-Chong, Chung, Sookja Kim, Xu, Aimin, Lam, Karen Siu-Ling., Chan, Koon Ho
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123368/
https://ncbi.nlm.nih.gov/pubmed/27884163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0136-x
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