Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

BACKGROUND: Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimer’s disease (AD). Increasing evidence suggests that insulin resistance plays an important role in AD pathogenesis, possibly due to abnormal GSK3β activa...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Ng, Roy Chun-Laam, Cheng, On-Yin, Jian, Min, Kwan, Jason Shing-Cheong, Ho, Philip Wing-Lok, Cheng, Kenneth King-Yip, Yeung, Patrick Ka Kit, Zhou, Lena Lei, Hoo, Ruby Lai-Chong, Chung, Sookja Kim, Xu, Aimin, Lam, Karen Siu-Ling., Chan, Koon Ho
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123368/
https://ncbi.nlm.nih.gov/pubmed/27884163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0136-x
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