TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

BACKGROUND: Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor cells from intracellular reactive oxygen species (ROS)-associated apoptosis. How...

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Veröffentlicht in:J Hematol Oncol
Hauptverfasser: Qian, Sixuan, Li, Jianyong, Hong, Ming, Zhu, Yu, Zhao, Huihui, Xie, Yue, Huang, Jiayu, Lian, Yun, Li, Yanru, Wang, Shuai, Mao, Jianping, Chen, Yaoyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123356/
https://ncbi.nlm.nih.gov/pubmed/27884166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0360-4
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