Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer’s disease (AD). Angiotensin-converting enzyme-2 (ACE-2) degrades Ang II t...

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Publicado en:Alzheimers Res Ther
Main Authors: Kehoe, Patrick Gavin, Wong, Steffenny, AL Mulhim, Noura, Palmer, Laura Elyse, Miners, J. Scott
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123239/
https://ncbi.nlm.nih.gov/pubmed/27884212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0217-7
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