Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome

OBJECTIVE: Extreme obesity is a core phenotypic feature of Prader–Willi syndrome (PWS). Among numerous metabolic regulators, the endocannabinoid (eCB) system is critically involved in controlling feeding, body weight, and energy metabolism, and a globally acting cannabinoid-1 receptor (CB(1)R) block...

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Foilsithe in:Mol Metab
Main Authors: Knani, Ibrahim, Earley, Brian J., Udi, Shiran, Nemirovski, Alina, Hadar, Rivka, Gammal, Asaad, Cinar, Resat, Hirsch, Harry J., Pollak, Yehuda, Gross, Itai, Eldar-Geva, Talia, Reyes-Capo, Daniela P., Han, Joan C., Haqq, Andrea M., Gross-Tsur, Varda, Wevrick, Rachel, Tam, Joseph
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2016
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123200/
https://ncbi.nlm.nih.gov/pubmed/27900261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.10.004
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