Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression

Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown. Here by using genetic association data and functional characterization, we demonstrate that rs4487645 G>T, the most highly associated varian...

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Vydáno v:Nat Commun
Hlavní autoři: Li, Ni, Johnson, David C., Weinhold, Niels, Studd, James B., Orlando, Giulia, Mirabella, Fabio, Mitchell, Jonathan S., Meissner, Tobias, Kaiser, Martin, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J., Houlston, Richard S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123067/
https://ncbi.nlm.nih.gov/pubmed/27882933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13656
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