Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

The lymphatic vessel endothelial receptor LYVE-1 is implicated in the uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan and depends on receptor clustering and higher order ligand organization for durable binding in lymph...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Banerji, Suneale, Lawrance, William, Metcalfe, Clive, Briggs, David C., Yamauchi, Akira, Dushek, Omer, van der Merwe, P. Anton, Day, Anthony J., Jackson, David G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122770/
https://ncbi.nlm.nih.gov/pubmed/27733683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.736926
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