An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy

Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a c...

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Detalles Bibliográficos
Publicado en:Front Cell Infect Microbiol
Main Authors: Golovliov, Igor, Lindgren, Helena, Eneslätt, Kjell, Conlan, Wayne, Mosnier, Amandine, Henry, Thomas, Sjöstedt, Anders
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122580/
https://ncbi.nlm.nih.gov/pubmed/27933275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2016.00152
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