An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy

Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a c...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Infect Microbiol
Hauptverfasser: Golovliov, Igor, Lindgren, Helena, Eneslätt, Kjell, Conlan, Wayne, Mosnier, Amandine, Henry, Thomas, Sjöstedt, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122580/
https://ncbi.nlm.nih.gov/pubmed/27933275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2016.00152
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