The Effect of Donepezil on Arousal Threshold and Apnea–Hypopnea Index. A Randomized, Double-Blind, Cross-Over Study

Rationale: Obstructive sleep apnea (OSA) has multiple pathophysiological causes. A low respiratory arousal threshold (ArTh) and a high loop gain (unstable ventilatory control) can contribute to recurrent respiratory events in patients with OSA. Prior studies have shown that donepezil, an acetylcholi...

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Pubblicato in:Ann Am Thorac Soc
Autori principali: Li, Yanru, Owens, Robert L., Sands, Scott, Orr, Jeremy, Moraes, Walter, DeYoung, Pamela, Smales, Erik, Jen, Rachel, Malhotra, Atul
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122481/
https://ncbi.nlm.nih.gov/pubmed/27442715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1513/AnnalsATS.201605-384OC
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