NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing

Colorectal cancer (CRC) arises from mutations in a subset of genes. We investigated the germline and somatic mutation spectrum of patients with CRC in Taiwan by using the AmpliSeq Cancer Hotspot Panel V2. Fifty paired freshly frozen stage 0–IV CRC tumors and adjacent normal tissue were collected. Bl...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Chang, Pi-Yueh, Chen, Jinn-Shiun, Chang, Nai-Chung, Chang, Shih-Cheng, Wang, Mei-Chia, Tsai, Shu-Hui, Wen, Ying-Hao, Tsai, Wen-Sy, Chan, Err-Cheng, Lu, Jang-Jih
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122332/
https://ncbi.nlm.nih.gov/pubmed/27121310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8885
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