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Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease

BACKGROUND: The pathological features of Parkinson’s disease (PD) include an abnormal accumulation of α-synuclein in the surviving dopaminergic neurons. Though PD is multifactorial, several epidemiological reports show an increased incidence of PD with co-exposure to pesticides such as Maneb and par...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Kumar, Ashutosh, Ganini, Douglas, Mason, Ronald P.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122029/
https://ncbi.nlm.nih.gov/pubmed/27884192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0135-y
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