Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number v...

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Publicado no:Nat Commun
Main Authors: Dölle, Christian, Flønes, Irene, Nido, Gonzalo S., Miletic, Hrvoje, Osuagwu, Nelson, Kristoffersen, Stine, Lilleng, Peer K., Larsen, Jan Petter, Tysnes, Ole-Bjørn, Haugarvoll, Kristoffer, Bindoff, Laurence A., Tzoulis, Charalampos
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121427/
https://ncbi.nlm.nih.gov/pubmed/27874000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13548
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