Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells

In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide RNAi screen was performed in endothelial cells and cross-referenced with GWAS-data sets. Here we show that the activin-like kin...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Kraehling, Jan R., Chidlow, John H., Rajagopal, Chitra, Sugiyama, Michael G., Fowler, Joseph W., Lee, Monica Y., Zhang, Xinbo, Ramírez, Cristina M., Park, Eon Joo, Tao, Bo, Chen, Keyang, Kuruvilla, Leena, Larriveé, Bruno, Folta-Stogniew, Ewa, Ola, Roxana, Rotllan, Noemi, Zhou, Wenping, Nagle, Michael W., Herz, Joachim, Williams, Kevin Jon, Eichmann, Anne, Lee, Warren L., Fernández-Hernando, Carlos, Sessa, William C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121336/
https://ncbi.nlm.nih.gov/pubmed/27869117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13516
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