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Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
In humans and animals lacking functional LDL receptor (LDLR), LDL from plasma still readily traverses the endothelium. To identify the pathways of LDL uptake, a genome-wide RNAi screen was performed in endothelial cells and cross-referenced with GWAS-data sets. Here we show that the activin-like kin...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5121336/ https://ncbi.nlm.nih.gov/pubmed/27869117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13516 |
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