Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

Hereditary spastic paraplegia (HSP) is a neurological syndrome characterized by degeneration of central nervous system (CNS) axons. Mutated HSP proteins include myelin proteolipid protein (PLP) and axon-enriched proteins involved in mitochondrial function, smooth endoplasmic reticulum (SER) structur...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Yin, Xinghua, Kidd, Grahame J., Ohno, Nobuhiko, Perkins, Guy A., Ellisman, Mark H., Bastian, Chinthasagar, Brunet, Sylvain, Baltan, Selva, Trapp, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119941/
https://ncbi.nlm.nih.gov/pubmed/27872255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201607099
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