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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
CD8(+) T cells recognizing tumor-specific antigens are detected in cancer patients but are dysfunctional. Here we developed a tamoxifen-inducible liver cancer mouse model with a defined oncogenic driver antigen (SV40 large T-antigen) to follow the activation and differentiation of naive tumor-specif...
שמור ב:
הוצא לאור ב: | Immunity |
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Main Authors: | , , , , , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
2016
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5119632/ https://ncbi.nlm.nih.gov/pubmed/27521269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.07.011 |
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