Ligation of CD40 in Human Müller Cells Induces P2X(7) Receptor–Dependent Death of Retinal Endothelial Cells

PURPOSE: Cluster of differentiation 40 (CD40) is required for retinal capillary degeneration in diabetic mice, a process mediated by the retinal endothelial cells (REC) death. However, CD40 activates prosurvival signals in endothelial cells. The purpose of this study was to identify a mechanism by w...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Portillo, Jose-Andres C., Lopez Corcino, Yalitza, Dubyak, George R., Kern, Timothy S., Matsuyama, Shigemi, Subauste, Carlos S.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2016
Fag:
Retina
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119488/
https://ncbi.nlm.nih.gov/pubmed/27893093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20301
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