Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity

Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L-arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase-II (Arg-II) in vascular endothelial cells promote uncoupling of endo...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Huang, Ji, Rajapakse, Angana, Xiong, Yuyan, Montani, Jean-Pierre, Verrey, François, Ming, Xiu-Fen, Yang, Zhihong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118905/
https://ncbi.nlm.nih.gov/pubmed/27920727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00560
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