Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2

BACKGROUND: Imprinted loci are paradigms of epigenetic regulation and are associated with a number of genetic disorders in human. A key characteristic of imprints is the presence of a gametic differentially methylated region (gDMR). Previous studies have indicated that DNA methylation lost from gDMR...

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Dettagli Bibliografici
Pubblicato in:Epigenetics Chromatin
Autori principali: Thakur, Avinash, Mackin, Sarah-Jayne, Irwin, Rachelle E., O’Neill, Karla M., Pollin, Gareth, Walsh, Colum
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118886/
https://ncbi.nlm.nih.gov/pubmed/27895716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0104-2
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