CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression is elevated in HSCs and positively correlates with liver fibrosis severity in human liver biopsies. Transforming growth factor-beta (TGF-β) selecti...

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Publicado no:Nat Commun
Main Authors: Wu, Xingxin, Wu, Xudong, Ma, Yuxiang, Shao, Fenli, Tan, Yang, Tan, Tao, Gu, Liyun, Zhou, Yang, Sun, Beicheng, Sun, Yang, Wu, Xuefeng, Xu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118555/
https://ncbi.nlm.nih.gov/pubmed/27853137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13498
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