Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas

DLC1 encodes GTPase-activating protein with a well-documented tumor suppressor activity. This gene is downregulated in various tumors through aberrant promoter hypermethylation. Five different DLC1 isoforms can be transcribed from alternative promoters. Tumor-related DNA methylation of the DLC1 isof...

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Bibliographic Details
Published in:J Neurooncol
Main Authors: Bujko, M., Kober, P., Rusetska, N., Wakuła, M., Goryca, K., Grecka, E., Matyja, E., Neska, J., Mandat, T., Bonicki, W., Siedlecki, J. A.
Format: Artigo
Language:Inglês
Published: Springer US 2016
Subjects:
Laboratory Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118400/
https://ncbi.nlm.nih.gov/pubmed/27614886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-016-2261-3
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