Small-angle x-ray scattering of calpain-5 reveals a highly open conformation among calpains

Calpain-5 is a calcium-activated protease expressed in the retina. Mutations in calpain-5 cause autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM#193235). The structure of calpain-5 has not been determined, thus hindering the investigation of its proteolytic targets and path...

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Detaylı Bibliyografya
Yayımlandı:J Struct Biol
Asıl Yazarlar: Gakhar, Lokesh, Bassuk, Alexander G., Velez, Gabriel, Khan, Saif, Yang, Jing, Tsang, Stephen H., Mahajan, Vinit B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118095/
https://ncbi.nlm.nih.gov/pubmed/27474374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2016.07.017
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