SORL1 variants across Alzheimer's disease European American cohorts

The accumulation of the toxic Aβ peptide in Alzheimer's disease (AD) largely relies upon an efficient recycling of amyloid precursor protein (APP). Recent genetic association studies have described rare variants in SORL1 with putative pathogenic consequences in the recycling of APP. In this wor...

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Bibliografiske detaljer
Udgivet i:Eur J Hum Genet
Main Authors: Fernández, Maria Victoria, Black, Kathleen, Carrell, David, Saef, Ben, Budde, John, Deming, Yuetiva, Howells, Bill, Del-Aguila, Jorge L, Ma, Shengmei, Bi, Catherine, Norton, Joanne, Chasse, Rachel, Morris, John, Goate, Alison, Cruchaga, Carlos
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117924/
https://ncbi.nlm.nih.gov/pubmed/27650968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.122
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