A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus

The rising problem of antimicrobial resistance in Staphylococcus aureus necessitates the discovery of novel therapeutic targets for small-molecule intervention. A major obstacle of drug discovery is identifying the target of molecules selected from high-throughput phenotypic assays. Here, we show th...

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Publicado no:Cell Chem Biol
Main Authors: Choby, Jacob E., Mike, Laura A., Mashruwala, Ameya A., Dutter, Brendan F., Dunman, Paul M., Sulikowski, Gary A., Boyd, Jeffrey M., Skaar, Eric P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117899/
https://ncbi.nlm.nih.gov/pubmed/27773628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.09.012
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