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The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells
The MDMX (MDM4) oncogene is amplified or overexpressed in a significant percentage of human tumors. MDMX is thought to function as an oncoprotein by binding p53 tumor suppressor protein to inhibit p53-mediated transcription, and by complexing with MDM2 oncoprotein to promote MDM2-mediated degradatio...
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| Publicado no: | Oncogenesis |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117848/ https://ncbi.nlm.nih.gov/pubmed/27694836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.62 |
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