The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells

The MDMX (MDM4) oncogene is amplified or overexpressed in a significant percentage of human tumors. MDMX is thought to function as an oncoprotein by binding p53 tumor suppressor protein to inhibit p53-mediated transcription, and by complexing with MDM2 oncoprotein to promote MDM2-mediated degradatio...

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Publicat a:Oncogenesis
Autors principals: Matijasevic, Z, Krzywicka-Racka, A, Sluder, G, Gallant, J, Jones, S N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117848/
https://ncbi.nlm.nih.gov/pubmed/27694836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.62
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