Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and anti-tumor immunity in breast cancer

The unfolded protein response is an endoplasmic reticulum stress pathway mediated by the protein chaperone glucose regulated-protein 78 (GRP78). Metabolic analysis of breast cancer cells shows that GRP78 silencing increases the intracellular concentrations of essential polyunsaturated fats including...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Cook, Katherine L., Soto-Pantoja, David R., Clarke, Pamela A.G., Cruz, M. Idalia, Zwart, Alan, Wärri, Anni, Hilakivi-Clarke, Leena, Roberts, David D., Clarke, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117832/
https://ncbi.nlm.nih.gov/pubmed/27698188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2616
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