An Open-label, Dose-Escalation Phase 1 Study of anti-TYRP1 monoclonal antibody IMC-20D7S for patients with relapsed or refractory melanoma

PURPOSE: Tyrosinase-related protein-1 (TYRP1) is a transmembrane glycoprotein that is specifically expressed in melanocytes and melanoma cells. Preclinical data suggest that monoclonal antibodies targeting TYRP1 confer anti-melanoma activity. IMC-20D7S is a recombinant human IgG1 mAb targeting TYPR1...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Khalil, Danny N., Postow, Michael A., Ibrahim, Nageatte, Ludwig, Dale L., Cosaert, Jan, Kambhampati, Siva Rama Prasad, Tang, Shande, Grebennik, Dmitri, Kauh, John Sae Wook, Lenz, Heinz-Josef, Flaherty, Keith T., Hodi, F. Stephen, Lawrence, Donald P., Wolchok, Jedd D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117650/
https://ncbi.nlm.nih.gov/pubmed/27797971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1241
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