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Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq

Cellular heterogeneity can emerge from the expression of only one parental allele. However, it has remained controversial whether, or to what degree, random monoallelic expression of autosomal genes (aRME) is mitotically inherited (clonal) or stochastic (dynamic) in somatic cells, particularly in vi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Genet
Prif Awduron: Reinius, Björn, Mold, Jeff E., Ramsköld, Daniel, Deng, Qiaolin, Johnsson, Per, Michaëlsson, Jakob, Frisén, Jonas, Sandberg, Rickard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117254/
https://ncbi.nlm.nih.gov/pubmed/27668657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3678
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