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Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq

Cellular heterogeneity can emerge from the expression of only one parental allele. However, it has remained controversial whether, or to what degree, random monoallelic expression of autosomal genes (aRME) is mitotically inherited (clonal) or stochastic (dynamic) in somatic cells, particularly in vi...

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Foilsithe in:Nat Genet
Main Authors: Reinius, Björn, Mold, Jeff E., Ramsköld, Daniel, Deng, Qiaolin, Johnsson, Per, Michaëlsson, Jakob, Frisén, Jonas, Sandberg, Rickard
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117254/
https://ncbi.nlm.nih.gov/pubmed/27668657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3678
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