Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis

To obtain new information about Streptococcus pyogenes intrahost genetic variation during invasive infection, we sequenced the genomes of 2,954 serotype M1 strains recovered from a nonhuman primate experimental model of necrotizing fasciitis. A total of 644 strains (21.8%) acquired polymorphisms rel...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Eraso, Jesus M., Olsen, Randall J., Beres, Stephen B., Kachroo, Priyanka, Porter, Adeline R., Nasser, Waleed, Bernard, Paul E., DeLeo, Frank R., Musser, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116706/
https://ncbi.nlm.nih.gov/pubmed/27600505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00608-16
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