Co-expression of truncated and full-length tau induces severe neurotoxicity

Abundant tau inclusions are a defining hallmark of several human neurodegenerative diseases, including Alzheimer's disease. Protein fragmentation is a widely observed event in neurodegenerative proteinopathies. The relevance of tau fragmentation for the neurodegenerative process in tauopathies...

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Publicat a:Mol Psychiatry
Autors principals: Ozcelik, S, Sprenger, F, Skachokova, Z, Fraser, G, Abramowski, D, Clavaguera, F, Probst, A, Frank, S, Müller, M, Staufenbiel, M, Goedert, M, Tolnay, M, Winkler, D T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116481/
https://ncbi.nlm.nih.gov/pubmed/26830137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.228
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