Characterization of GABA(A) receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells

INTRODUCTION: Automated patch clamp is a recent but widely used technology to assess pre-clinical drug safety. With the availability of human neurons derived from pluripotent stem cells, this technology can be extended to determine CNS effects of drug candidates, especially those acting on the GABA(...

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Detalhes bibliográficos
Publicado no:J Pharmacol Toxicol Methods
Principais autores: Yuan, Nina Y., Poe, Michael M., Witzigmann, Christopher, Cook, James M., Stafford, Douglas, Arnold, Leggy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116268/
https://ncbi.nlm.nih.gov/pubmed/27544543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2016.08.006
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