HIV/HCV in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types

HIV/HCV co-infection accelerates progressive liver fibrosis, however the mechanisms remain poorly understood. HCV and HIV independently induce profibrogenic markers TGFβ1 (mediated by reactive oxygen species (ROS)) and NFκB in hepatocytes and hepatic stellate cells (HSC) in monoculture, however, the...

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Publicado en:Hepatology
Main Authors: Salloum, Shadi, Holmes, Jacinta A., Jindal, Rohit, Bale, Shyam S., Brisac, Cynthia, Alatrakchi, Nadia, Lidofsky, Anna, Kruger, Annie, Fusco, Dahlene N., Luther, Jay, Schaefer, Esperance, Lin, Wenyu, Yarmush, Martin L., Chung, Raymond T.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116014/
https://ncbi.nlm.nih.gov/pubmed/27531241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28766
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