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Optimizing effect sizes with imaging enrichment and outcome choices for mild Alzheimer’s disease clinical trials

Recent clinical trials in mild Alzheimer’s disease (AD) have enriched for amyloid-specific positron emission tomography imaging and used extended versions of the AD Assessment Scale-Cognitive Subscale (ADAS-Cog) in an effort to increase the sensitivity to detect treatment effects. We used data from...

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Veröffentlicht in:Alzheimer Dis Assoc Disord
Hauptverfasser: Chang, Timothy S., Teng, Edmond, Elashoff, David, Grill, Joshua D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116001/
https://ncbi.nlm.nih.gov/pubmed/27196535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WAD.0000000000000150
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