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Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3

The eukaryotic RNA exosome is an essential and conserved 3’ to 5’ exoribonuclease complex that degrades or processes nearly every class of cellular RNA. The nuclear RNA exosome includes a nine-subunit non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subunits to modulate their processive and distr...

詳細記述

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書誌詳細
出版年:Mol Cell
主要な著者: Zinder, John C., Wasmuth, Elizabeth V., Lima, Christopher D.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115963/
https://ncbi.nlm.nih.gov/pubmed/27818140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.09.038
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