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IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease

Lipopolysaccharide (LPS)-mediated activation of Toll-like receptors (TLRs) in hepatic macrophages and injury to hepatocytes are major contributors to the pathogenesis of alcoholic liver disease (ALD). However, the mechanisms by which TLR-dependent inflammatory responses and alcohol-induced hepatocel...

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Bibliographic Details
Published in:Hepatology
Main Authors: Zhou, Hao, Yu, Minjia, Zhao, Junjie, Martin, Bradley N., Roychowdhury, Sanjoy, McMullen, Megan R., Wang, Emily, Fox, Paul L., Yamasaki, Sho, Nagy, Laura E., Li, Xiaoxia
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115953/
https://ncbi.nlm.nih.gov/pubmed/27628766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28811
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