tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

Microbial pathogens adapt to the stress of infection by regulating transcription, translation and protein modification. We report that changes in gene expression in hypoxia-induced non-replicating persistence in mycobacteria—which models tuberculous granulomas—are partly determined by a mechanism of...

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Udgivet i:Nat Commun
Main Authors: Chionh, Yok Hian, McBee, Megan, Babu, I. Ramesh, Hia, Fabian, Lin, Wenwei, Zhao, Wei, Cao, Jianshu, Dziergowska, Agnieszka, Malkiewicz, Andrzej, Begley, Thomas J., Alonso, Sylvie, Dedon, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114619/
https://ncbi.nlm.nih.gov/pubmed/27834374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13302
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