Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

The nuclear lamina is essential for the proper structure and organization of the nucleus. Deregulation of A‐type lamins can compromise genomic stability, alter chromatin organization and cause premature vascular aging. Here, we show that accumulation of the lamin A precursor, prelamin A, inhibits 53...

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Vydáno v:Aging Cell
Hlavní autoři: Cobb, Andrew M., Larrieu, Delphine, Warren, Derek T., Liu, Yiwen, Srivastava, Sonal, Smith, Andrew J. O., Bowater, Richard P., Jackson, Stephen P., Shanahan, Catherine M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114580/
https://ncbi.nlm.nih.gov/pubmed/27464478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12506
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