Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

The nuclear lamina is essential for the proper structure and organization of the nucleus. Deregulation of A‐type lamins can compromise genomic stability, alter chromatin organization and cause premature vascular aging. Here, we show that accumulation of the lamin A precursor, prelamin A, inhibits 53...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Cobb, Andrew M., Larrieu, Delphine, Warren, Derek T., Liu, Yiwen, Srivastava, Sonal, Smith, Andrew J. O., Bowater, Richard P., Jackson, Stephen P., Shanahan, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114580/
https://ncbi.nlm.nih.gov/pubmed/27464478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12506
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