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Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest

The WRN helicase/exonuclease is mutated in Werner syndrome of genomic instability and premature aging. WRN-depleted fibroblasts, although remaining largely viable, have a reduced capacity to maintain replication forks active during a transient hydroxyurea-induced arrest. A strand exchange protein, R...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Kehrli, Keffy, Phelps, Michael, Lazarchuk, Pavlo, Chen, Eleanor, Monnat, Ray, Sidorova, Julia M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114403/
https://ncbi.nlm.nih.gov/pubmed/27672210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708594
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