Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations

OBJECTIVES: Human complement C4 is sophisticatedly complex with multiple layers of diversity. This study aims to elucidate the CNVs of C4A and C4B in disease risk of SLE, and compare the basis of race-specific C4A-deficiency in East-Asians (EA) and Europeans. PATIENTS AND METHODS: Our EA study-popul...

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Publicado no:Arthritis Rheumatol
Main Authors: Chen, Ji Yih, Wu, Yee Ling, Mok, Mo Yin, Wu, Yeong-Jian Jan, Lintner, Katherine E., Wang, Chin-Man, Chung, Erwin K., Yang, Yan, Zhou, Bi, Wang, Huanyu, Yu, Dennis, Alhomosh, Alaaedin, Jones, Karla, Spencer, Charles H., Nagaraja, Haikady N., Lau, Yu Lung, Lau, Chak-Sing, Yu, C. Yung
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5114127/
https://ncbi.nlm.nih.gov/pubmed/26814708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39589
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