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Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans

Interindividual gene copy-number variation (CNV) of complement component C4 and its associated polymorphisms in gene size (long and short) and protein isotypes (C4A and C4B) probably lead to different susceptibilities to autoimmune disease. We investigated the C4 gene CNV in 1,241 European Americans...

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Autori principali: Yang, Yan , Chung, Erwin K. , Wu, Yee Ling , Savelli, Stephanie L. , Nagaraja, Haikady N. , Zhou, Bi , Hebert, Maddie , Jones, Karla N. , Shu, Yaoling , Kitzmiller, Kathryn , Blanchong, Carol A. , McBride, Kim L. , Higgins, Gloria C. , Rennebohm, Robert M. , Rice, Robert R. , Hackshaw, Kevin V. , Roubey, Robert A. S. , Grossman, Jennifer M. , Tsao, Betty P. , Birmingham, Daniel J. , Rovin, Brad H. , Hebert, Lee A. , Yu, C. Yung 
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Human Genetics 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867093/
https://ncbi.nlm.nih.gov/pubmed/17503323
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